Netshine Hosting

Yes, this is possible by the use of 'add-on domains'.  This enables you to point different domain names to different folders on your hosting account.  However, this arrangement is not suitable for reselling hosting accounts to other people, and each addon domain also uses up 1 sub-domain from your allowance. The number of additional sites you can host depends on the hosting package you have, but even a Starter account allows for up to 5 addon domains.